Mixed Integer Neural Inverse Design

In computational design and fabrication, neural networks are becoming important surrogates for bulky forward simulations. A long-standing, intertwined question is that of inverse design: how to compute a design that satisfies a desired target performance? Here, we show that the piecewise linear property, very common in everyday neural networks, allows for an inverse design formulation based on mixed-integer linear programming. Our mixed-integer inverse design uncovers globally optimal or near optimal solutions in a principled manner. Furthermore, our method significantly facilitates emerging, but challenging, combinatorial inverse design tasks, such as material selection. For problems where finding the optimal solution is not desirable or tractable, we develop an efficient yet near-optimal hybrid optimization. Eventually, our method is able to find solutions provably robust to possible fabrication perturbations among multiple designs with similar performances

Mixed Integer Neural Inverse Design

In computational design and fabrication, neural networks are becoming important surrogates for bulky forward simulations. A long-standing, intertwined question is that of inverse design: how to compute a design that satisfies a desired target performance? Here, we show that the piecewise linear property, very common in everyday neural networks, allows for an inverse design formulation based on mixed-integer linear programming. Our mixed-integer inverse design uncovers globally optimal or near optimal solutions in a principled manner. Furthermore, our method significantly facilitates emerging, but challenging, combinatorial inverse design tasks, such as material selection. For problems where finding the optimal solution is not desirable or tractable, we develop an efficient yet near-optimal hybrid optimization. Eventually, our method is able to find solutions provably robust to possible fabrication perturbations among multiple designs with similar performances

A systematic review of the use of commercial wearable activity trackers for monitoring recovery in individuals undergoing total hip replacement surgery

The innovation of wearable devices is advancing rapidly. Activity monitors can be used to improve the total hip replacement (THR) patients' recovery process and reduce costs. This systematic review assessed the body-worn accelerometers used in studies to enhance the rehabilitation process and monitor THR patients. Electronic databases such as Cochrane Database of Systematic Reviews library, CINAHL CompleteVR, Science Citation Index, and MedlineVR from January 2000 to January 2022 were searched. Due to inclusion criteria, fourteen eligible studies that utilised commercial wearable technology to monitor physical activity both before and after THR were identified. Their evidence quality was assessed with RoB 2.0 and ROBINS-I. This study demonstrates that wearable device technology might be feasible to predict, monitor, and detect physical activity following THR. They could be used as a motivational tool to increase patients' mobility and enhance the recovery process. Also, wearable activity monitors could provide a better insight into the individual's activity level in contrast to subjective self-reported questionnaires. However, they have some limitations, and further evidence is needed to establish this technology as the primary device in THR rehabilitation

The morphological characters of the male external genitalia of the European hedgehog (Erinaceus Europaeus)

This study was conducted to depict anatomical characteristics of the penis of he­dgehog. Seven sexually mature male European hedgehogs were used. Following anaesthesia, the animals were scarified with chloroform inhalation. Gross penile characteristics such as length and diameter were thoroughly explored and measu­red using digital callipers. Tissue samples stained with haematoxylin and eosin and Masson’s trichrome for microscopic analysis. The penis of the European hedgehog was composed of a pair of corpus cavernosum penis and the glans penis without corpus spongiosum penis. The urethra at the end of penis, protruded as urethral process, on both sides of which two black nail-like structures, could be observed. The lower part was rounded forming a blind sac (sacculus urethralis) with a me­dian split below the urethra. Microscopically, the penile bulb lacked the corpus spongiosum penis, but, corpus spongiosum glans was seen at the beginning of the free part. In the European hedgehog, entirely stratified squamous epithelium of penile urethra, absence of corpus spongiosum penis around the urethra and bilateral urethral glands are basically different compared with other mammals. This information is expected to contribute to comparative penile morphology as well as for testing phylogenic hypotheses and expanding knowledge about reproductive biology in this animal. (Folia Morphol 2018; 77, 2: 293–300

Identification of a De novo 3bp deletion in CRYBA1/A3 gene in Autosomal dominant congenital cataract

Autosomal dominant congenital cataract (ADCC) is the most common form of inherited cataracts and accounts for one-third of congenital cataracts. Heterozygous null mutations in the crystallin genes are the major cause of the ADCC. This study aims to detect the mutational spectrum of four crystallin genes, CRYBA1/A3, CRYBB1, CRYBB2 and CRYGD in an Iranian family. Genomic DNA was isolated from whole blood cells from theproband and other family members. The coding regions and flanking intronicsequences of crystalline genes were analyzed by Sanger sequencing in aproband with ADCC. The identified mutation was further evaluated in available family members. To predict the potential protein partners of CRYBA1/A3, we also used an in-silico analysis. A de novo heterozygous deletion (c.272-274delGAG, p.G91del) in exon 4 of CRYBA1/A3 gene, leading to a deletion of Glycine at codon 91 was found. This genetic variation did not change the reading frame of CRYBA1 protein. In conclusion, we identified a de novo in-frame 3-bp deletion in the proband with an autosomal dominant congenital cataract, but not in her parents, in an Iranian family. This mutation has occurred de novo on a paternal gamete during spermatogenesis. The in-silico results predicted the interaction of CRYBA1 protein with the other CRY as well as proteins responsible for eye cell signaling. � 2016 Tehran University of Medical Sciences. All rights reserved

Combined Economic Dispatch and Reliability in Power System by Using PSO-SIF Algorithm

Reliability investigation has always been one of the most important issues in power systems planning. The outages rate in power system reflects the fact that more attentions should be paid on reliability indices to supply consumers with uninterrupted power. Using reliability indices in economic dispatch problem may lead to the system load demand with high reliability and low probability of power's outage rate. In this paper, the Economic Dispatch (ED) problem is optimized using the reliability indices. That is, ED problem and system reliability are proposed as Combined Economic Dispatch and Reliability (CEDR) problem. In CEDR problem, it is tried to utilize generating units in a way that we have high reliability in supplying the system load demand as well as the minimum fuel costs. Due to multi-objective and non-convex characteristics of this problem, Particle Swarm Optimization with Smart Inertia Factor (PSO-SIF) is used to solve the problem. In this research, the ED of power plants is successfully implemented in two systems with 6 and 26 generating units considering emission and system reliability

Assessment of Heavy Metals Concentrations in Roadside Canola Fields in Mazandaran Province, Iran

Contamination of agricultural products with heavy metals in soil and air is considered as serious threat to the quality and safety of these products. Cars and vehicles are among the major sources of heavy metals such as lead, iron and copper in the environment surrounding roads and highways. According to carcinogenic and destructive effects of these elements on human health, the aim of this study is to measure the concentrations of lead, iron and copper resulting from the traffic of vehicles available in the soil and canola plants growing in the central regions of MAZANDARAN province in Iran. In this research, sampling was conducted randomly and the values of mentioned elements were measured using flame atomic absorption device according to standard methods. The results showed that the levels of lead, iron and copper elements were higher in canola plant samples, including root, aerial parts and seeds, compared with the respective cultivated soils. The results indicated that the contamination of canola plant with mentioned pollutants has been mostly through aerial parts compared to the soil

Human agt-p.Met268thr and coronary heart disease risk: A case-control study and meta-analysis

Summary Background. Polymorphisms in genes, which is involved in the renin–angiotensin system, play an important role in the pathogenesis of coronary heart disease (CHD). Polymorphism of c.803T>C in the human angiotensinogen gene results in methionine (M) to threonine (T) substitution at codon 268 (p.Met268Thr), which traditionally has been known as M235T. This polymorphism may contribute to cardiovascular diseases. Objectives. The aim of this study was to investigate the association between p.Met268Thr polymorphism in the angiotensinogen gene and coronary heart disease (CHD) through a case-control study, which is followed by a meta-analysis. Material and methods. In the case-control study, c.803T>C genotyping of 217 subjects (102 CHD cases vs 115 controls) was investigated by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. In the meta-analysis, 31 studies were included, reflecting 12,028 people with CHD and 16,362 healthy controls. Results. The data from the case-control study revealed that MT (OR, 1.875; 95%CI, 1.060–3.316; p = 0.031) and TT (OR, 3.389; 95%CI, 1.251–9.179; p = 0.016) genotypes are significantly associated with CHD. The meta-analysis revealed a significant association in the recessive model (OR, 1.156; 95%CI, 1.011–1.321; p = 0.034). Conclusions. Although the pooled OR of the meta-analysis showed that there is an increased risk of CHD conferred by p.Met268Thr of the AGT gene, this association was weak, which could be attributed to a bias in publications. © Copyright by Wydawnictwo Continuo

Magnetic-field dependence of the critical currents in a periodic coplanar array of narrow superconducting strip

We calculate the magnetic-field dependence of the critical current due to both geometrical edge barriers and bulk pinning in a periodic coplanar array of narrow superconducting strips. We find that in zero or low applied magnetic fields the critical current can be considerably enhanced by the edge barriers, but in modest applied magnetic fields the critical current reduces to that due to bulk pinning alone.Comment: 23 pages, 7 figure

Modelling of silver modules incorporating a lambertian rear reflector

Modules incorporating cells which are bifacial and narrow can make use of rear reflectors to capture most of the incident sunlight while covering only a fraction of the module area with cells. Sliver® cells, invented and developed at the ANU, meet these criteria. In this paper we analyse the performance limits of such modules for the case where a diffuse (lambertian) reflector is used. The analysis is carried out for various cell thicknesses, cell spacings and reflectivities of the lambertian reflector. The results show that excellent performance can be realised despite the simplicity of the structure. A module with a 50% coverage with 70µm thick cells can capture up to 84% of the light entering the module. Importantly, the performance of this kind of module is insensitive to module orientation. The results of the analytical model are compared with ray tracing studies and measurements and are shown to be in good agreement. It is concluded that significant module cost reductions can be achieved for only modest reductions in performance by covering half or less of the module surface with cells